Preferential antagonism of the interactions of the integrin allbf3 with immobilized glycoprotein ligands by snake-venom RGD (Arg-Gly-Asp)
نویسنده
چکیده
Xinjie LU,* Janice A. WILLIAMS,t John J. DEADMAN,* Gary P. SALMON,*§ Vijay V. KAKKAR,* J. Michael WILKINSON,T¶ Dominique BARUCH,11 Kalwant S. AUTHI* and Salman RAHMAN*,** *Platelet Section, Thrombosis Research Institute, 1 B Manresa Road, London SW3 6LR, U.K., tDepartment of Applied Pharmacology, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, U.K., IDepartment of Biochemistry and Cell Biology, Huntarian Institute, Royal College of Surgeons, 35-43 Lincoln's Inn Fields, London WC2A 2PN, U.K., and IIINSERM U. 143, Hopital de Bic6tre, 94275 Le Kremlin Bicetre Cedex, France
منابع مشابه
The integrin tilbfl 3 contains distinct and interacting binding sites for snake - venom
We have previously demonstrated [Lu, Williams, Deadman, Salmon, Kakkar, Wilkinson, Baruch, Authi and Rahman (1994) Biochem. J. 304, 929-936] the preferential antagonism of the interactions of the integrin aIIbflb on activated platelets with three immobilized glycoprotein ligands (fibrinogen, fibronectin and von Willebrand factor) by a selected panel of snake-venom RGD (Arg-Gly-Asp)-containing p...
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